Most common side effects to be ready for

These side effects may take some lifestyle adjustments

JYNARQUE may cause side effects, including excessive thirst and urination. These side effects are related to how JYNARQUE works in the kidneys.

Why do these side effects happen?

Vasopressin works differently in normal kidney cells. There, it helps control the amount of water in your body. When vasopressin is blocked, your body holds on to less water, which could make you thirstier and give you the urge to urinate more.

In clinical studies, just under 2 in 3 people (64%) felt thirsty while taking JYNARQUE

Practical step:

Try taking a water bottle with you everywhere so you always have something to drink

In clinical studies, just under 3 in 4 people (70%) had increased urination, including needing to wake up from sleep to urinate, urinating greater amounts, and urinating more often during the day

Practical step:

Wherever you go, plan ahead by finding out where the restrooms are

Practical step:

Take your first JYNARQUE dose upon waking and the second dose exactly 8 hours later and you may be able to reduce the need to wake up to urinate


In a clinical study, most people adjusted to taking JYNARQUE and were able to continue treatment

For people who took JYNARQUE in clinical trials, the first 2 to 4 months were critical to seeing if they could adjust to side effects like thirst, frequent urination, and waking up to urinate. Most people who made it past the early period with JYNARQUE stayed with it for the duration.

  • In a clinical study of patients with CKD stages 2-4, after the first 5 weeks, these side effects were reported less often

In a clinical study of patients with CKD stages 1-3, nearly all patients who took JYNARQUE were able to keep taking it every day

88% of people taking JYNARQUE were able to do so every day 90% of the time

  • 75% of patients who made it to 3 years with JYNARQUE said they could keep taking their current dose for as long as their doctor tells them to

If you are younger or early in your disease, these side effects might be worse.

If you are early in your disease and have trouble tolerating JYNARQUE, you can stop. At a later date, if you and your doctor agree it is right for you, you can start taking JYNARQUE again.