JYNARQUE® (tolvaptan) may cause serious side effects

Take JYNARQUE twice a day, unless advised otherwise by your doctor.

Serious side effects may include:

  • Liver injuries. Learn more about liver injuries and the JYNARQUE REMS Safety Program here
  • Too much sodium in your blood (hypernatremia) and loss of too much body fluid (dehydration). In some cases, dehydration can lead to extreme loss of body fluid called hypovolemia. You should drink water when you are thirsty and throughout the day and night. Stop taking JYNARQUE and call your healthcare provider if you cannot drink enough water for any reason, such as not having access to water, or vomiting or diarrhea. Tell your healthcare provider if you get any of the following symptoms:
    • dizziness
    • fainting
    • weight loss
    • a change in the way your heart beats
    • feeling confused or weak

Call your healthcare provider right away if you have any of the above symptoms.