JYNARQUE side effects and REMS
Serious side effects of JYNARQUE® (tolvaptan): what to watch out for
- Liver injuries. JYNARQUE can cause serious and potentially fatal liver injury. While you are taking JYNARQUE, you will take part in the Risk Evaluation and Mitigation Strategy (REMS) Program that will have your blood work monitored by your nephrologist to reduce your risk of liver injury. Learn more about liver injuries and the JYNARQUE REMS Program here
- Too much sodium in your blood (hypernatremia) and loss of too much body fluid (dehydration). In some cases, dehydration can lead to extreme loss of body fluid called hypovolemia. You should drink water when you are thirsty and throughout the day and night
- Stop taking JYNARQUE and call your healthcare provider if you cannot drink enough water for any reason, such as not having access to water, or vomiting or diarrhea
- Tell your healthcare provider if you get any of the following symptoms:
- weight loss
- a change in the way your heart beats
- feeling confused or weak
Call your healthcare provider right away if you have any of the serious symptoms above.
Common side effects with JYNARQUE
The most common side effects caused by JYNARQUE include excessive thirst and increased urination.
In clinical studies,
- About 2 in 3 people (64%) felt thirsty while taking JYNARQUE
- About 3 in 4 people (70%) had increased urination, including needing to wake up at night to urinate, urinating greater amounts, and urinating more often during the day
These are not all the possible side effects of JYNARQUE. Talk to your healthcare provider about any side effect that bothers you or that does not go away.
Stay on Track
Being patient with yourself and with the adjustments in your lifestyle may help you stay focused on slowing the decline of your kidney function.
Managing common side effects can be challenging. In clinical studies, JYNARQUE wasn’t right for everyone. Eight percent of people taking JYNARQUE had to stop because of these common side effects. While on your treatment journey, it might help to remember that most people taking JYNARQUE found the side effects manageable.
In a clinical study of patients with chronic kidney disease (CKD) stages 2 to 4, most (95.8%) people adjusted to taking JYNARQUE and were able to continue treatment
- Most people (95.8%) who continued in the study past the first 5 weeks with JYNARQUE stayed with it for at least 1 year
- Side effects may vary
In a clinical study of patients with CKD stages 1 to 3, nearly all patients who took JYNARQUE were able to keep taking it every day
- 75% of patients who made it to 3 years with JYNARQUE said they could keep taking their current dose for as long as their doctor tells them to
Talk to a real patient
If you have questions about treatment with JYNARQUE or about autosomal dominant polycystic kidney disease (ADPKD), check out the Peer Mentor Program.
You can ask your questions to real people who are already on treatment.