How do I take JYNARQUE® (tolvaptan)?

You and your doctor will work to find the JYNARQUE dose that is right for you

Take JYNARQUE twice a day, unless advised otherwise by your doctor.

  • The starting dose for JYNARQUE is 60 mg/day
  • Your doctor might increase your dose of JYNARQUE to make sure it’s doing the most it can

JYNARQUE comes in weekly blister packs, labeled with the days of the week

The morning and afternoon doses are clearly labeled “AM” and “PM”

  • Take the first dose upon waking; take the second dose 8 hours later. Taking your second dose 8 hours after the first can help reduce the need to wake up to urinate
  • It is important to take both JYNARQUE doses as prescribed to make sure it's working all day long
  • JYNARQUE may be taken with or without meals
  • If you miss a dose of JYNARQUE, do not double up. Take the next dose when you normally would
  • Do not drink grapefruit juice during treatment with JYNARQUE. This could cause you to have too much JYNARQUE in your blood

This chart may help you stay on time with your medication.

JYNARQUE tablets come in 5 different strengths*

90-mg tablets Pentagonal 90 OTSUKA 60-mg tablets Rectangular 60 OTSUKA 45-mg tablets Square 45 OTSUKA 30-mg tablets Round 30 OTSUKA OTSUKA 15 Triangular 15-mg tablets


*Not actual size. Not all dose strengths are packaged together.

3 dose combinations of JYNARQUE are available:

+ 90 mg 30 mg TARGET DOSE (120 mg): + 60 mg 30 mg MEDIUM DOSE (90 mg): 45 mg + 15 mg LOWEST DOSE (60 mg): 1ST TABLET (UPON WAKING) 2ND TABLET (8 HOURS LATER)
+ 90 mg 30 mg TARGET DOSE (120 mg) : + 60 mg 30 mg MEDIUM DOSE (90 mg) : 45 mg + 15 mg LOWEST DOSE (60 mg): 1ST TABLET (UPON WAKING ) 2ND TABLET (8 HOURS LATER )

Who should not take JYNARQUE?

Do not take JYNARQUE if you:

  • have severe liver problems
  • cannot feel if you are thirsty
  • have been told that your body fluids are too low
  • have been told that the amount of sodium in your blood is too high or too low
  • are allergic to tolvaptan or any of the ingredients in JYNARQUE. See the Medication Guide for a complete list of ingredients in JYNARQUE
  • are unable to urinate

What should I tell my healthcare provider before taking JYNARQUE?

Tell your healthcare provider about all your medical conditions, including if you:

  • have a history of sodium (salt) levels that are too low
  • are pregnant or plan to become pregnant. It is not known if tolvaptan will harm your unborn baby. Tell your healthcare provider if you become pregnant or think that you may be pregnant
  • are breastfeeding or plan to breastfeed. It is not known if tolvaptan passes into your breast milk. Do not breastfeed during your treatment with JYNARQUE. Talk to your healthcare provider about the best way to feed your baby during this time

Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.

  • Taking JYNARQUE with certain medicines could cause you to have too much tolvaptan in your blood. JYNARQUE should not be taken with certain medications. Your healthcare provider can tell you if it is safe to take JYNARQUE with other medicines
  • Do not start taking a new medicine without talking to your healthcare provider