Taking JYNARQUE

How do I take JYNARQUE® (tolvaptan)?

Dose schedule

You and your doctor will work to find the JYNARQUE dose that is right for you

The starting dose for JYNARQUE is 60 mg/day.

Your doctor might increase your dose of JYNARQUE to make sure it’s doing the most it can.

3 dose combinations of JYNARQUE are available*:

  • 45 mg 15 mg + 1 tablet st (upon waking) (8 hours later) 2 tablet nd
    45 mg 15 mg + 1 tablet st (upon waking) (8 hours later) 2 tablet nd
  • JYNARQUE comes in weekly blister packs, labeled with the days of the week

    The morning and afternoon doses are clearly labeled “AM” and “PM.”

  • + 60 mg 30 mg 1 tablet st (upon waking) (8 hours later) 2 tablet nd
    60 mg 30 mg + 1 tablet st (upon waking) (8 hours later) 2 tablet nd
  • JYNARQUE comes in weekly blister packs, labeled with the days of the week

    The morning and afternoon doses are clearly labeled “AM” and “PM.”

  • + 90 mg 30 mg 1 tablet st (upon waking) (8 hours later) 2 tablet nd
    30 mg 90 mg + 1 tablet st (upon waking) (8 hours later) 2 tablet nd
  • JYNARQUE comes in weekly blister packs, labeled with the days of the week

    The morning and afternoon doses are clearly labeled “AM” and “PM.”

*Not actual size.

Taking JYNARQUE

Some tips for taking JYNARQUE

Take JYNARQUE twice a day, unless advised otherwise by your doctor

Take the first dose upon waking; take the second dose 8 hours later. Taking your second dose 8 hours after the first can help reduce the need to wake up to use the bathroom at night

It is important to take both JYNARQUE doses as prescribed, to make sure it is working all day long

JYNARQUE may be taken with or without meals

If you miss a dose of JYNARQUE, do not double up. Take the next dose when you normally would

Do not drink grapefruit juice during treatment with JYNARQUE. This could cause you to have too much JYNARQUE in your blood

Other considerations

Who should not take JYNARQUE?

Do not take JYNARQUE if you:

  • have severe liver problems
  • cannot feel if you are thirsty
  • have been told that your body fluids are too low
  • have been told that the amount of sodium (salt) in your blood is too high or too low
  • are allergic to tolvaptan or any of the ingredients in JYNARQUE. See the MEDICATION GUIDE for a complete list of ingredients in JYNARQUE
  • are unable to urinate

What should I tell my healthcare provider before taking JYNARQUE?

Tell your healthcare provider about all your medical conditions, including if you:

  • have a history of sodium (salt) levels that are too low
  • are pregnant or plan to become pregnant. It is not known if tolvaptan will harm your unborn baby. Tell your healthcare provider if you become pregnant or think that you may be pregnant
  • are breastfeeding or plan to breastfeed. It is not known if tolvaptan passes into your breast milk. Do not breastfeed during your treatment with JYNARQUE. Talk to your healthcare provider about the best way to feed your baby during this time

Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.

  • Taking JYNARQUE with certain medicines could cause you to have too much tolvaptan in your blood. JYNARQUE should not be taken with certain medications. Your healthcare provider can tell you if it is safe to take JYNARQUE with other medicines
  • Do not start taking a new medicine without talking to your healthcare provider

Are you starting or currently taking JYNARQUE but can't make it to your required labwork?

We will come to you.

Learn more

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To help, we are offering a Home Collection Service available to all current, eligible patients taking JYNARQUE. A phlebotomist will be sent to your home to collect a blood sample for your REMS*-required blood work. The collection and processing will be free of charge to you.

 

If you are interested in this service, please reach out to your prescribing physician directly to get more details on this program or contact the Otsuka Patient Support Center at 1-855-242-7787 who are available from 9AM to 5PM EST.

*Risk Evaluation and Mitigation Strategy

Learn more